Hudson River Biotechnology (HRB), a Wageningen-based agricultural biotechnology company, and Computomics, a Tübingen-based bioinformatics company, announced to start offering an end-to-end solution using CRISPR-based gene editing for novel plant trait development.
This partnership combines Computomics’ expertise in accurate and precise machine learning-based identification of novel gene editing targets without off-target effects, and Hudson River Biotechnology’s CRISPR gene editing workflow, which is foreign-DNA-free. The collaboration between Computomics and Hudson River Biotechnology allows for a smooth handover from identification of disruptive gene editing targets to a precision gene editing workflow to deliver new plants to market rapidly.
Develering new crop varieties with desired traits
The joint solution, AccelATrait™, uses tailormade machine learning and CRISPR gene editing technologies to deliver new crop varieties with desired traits. Accel-A-Trait™ covers the entire workflow from experimental design to plant regeneration. It helps plant breeders develop new business based on novel traits and decreases time to market by 3-4 times.
In this partnership, Computomics is responsible for detecting, locating, and identifying novel causal targets using the latest machine learning technology. Hudson River Biotechnology performs the targeted editing using their rapid and validated CRISPR workflow. This workflow allows HRB to address recalcitrant species and offers benefits through transgene-free editing and single cell regeneration.
"Computomics and Hudson River Biotechnology complement each other perfectly in this partnership," says Dr. Sebastian J Schultheiss, Managing Director of Computomics. "We are working together to help plant breeders develop new varieties with improved characteristics in a shorter time and with less costs."
Rudi Ariaans, CEO of Hudson River Biotechnology, adds: “We see a clear benefit to this partnership, as many of our clients would like to access both the best in class bioinformatics capabilities and the best in transgene free CRISPR protocols to decrease the time to market for new crop varieties. AccelATrait brings these two together, allowing us to really accelerate molecular breeding for our clients. We look forward to being challenged to apply AccelATrait to previously unfeasible breeding projects, such as targeting polyploids and disruptive traits that can make a real difference.”